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Close-up of creamy Mississippi Chicken Casserole showing tender chicken, egg noodles, melted cheese, and sliced pepperoncini.
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5 from 1 vote

Mississippi Chicken Casserole

Mississippi Chicken Casserole is rich, creamy comfort food with a tangy twist. Ranch seasoned chicken, egg noodles, pepperoncini, and plenty of cheese baked until bubbly and golden.
Prep Time15 minutes
Cook Time1 hour
Total Time1 hour 15 minutes
Course: Main Course
Cuisine: American
Keyword: chicken casserole, Mississippi chicken casserole
Servings: 6
Calories: 964kcal
Author: Joanna Cismaru

Ingredients

  • 2 pounds boneless skinless chicken breasts cut into bite-size pieces
  • 12 ounces egg noodles
  • 1 tablespoon olive oil
  • 1 ounce ranch seasoning mix 1 packet
  • 1 teaspoon garlic powder
  • ½ teaspoon black pepper
  • 1 cup chicken broth low sodium or no sodium added
  • 1 cup sour cream
  • 1 cup cream cheese softened
  • ½ cup unsalted butter melted
  • ½ cup pepperoncini peppers sliced
  • ¼ cup pepperoncini juice
  • 2 cups mozzarella cheese shredded
  • 1 cup cheddar cheese shredded
  • chopped parsley for garnish (optional)
US Customary - Metric

Instructions

  • Preheat the oven to 375°F (190°C). Grease a 9×13-inch baking dish. Cook 12 ounces of egg noodles in salted water until just al dente. Drain and set aside.
    process shots showing how to make mississippi chicken casserole.
  • Heat 1 tablespoon of olive oil in a large skillet over medium-high heat. Add the chicken pieces and season with 1 packet of ranch seasoning, 1 teaspoon of garlic powder, and ½ teaspoon of black pepper. Cook for 5 to 6 minutes until lightly browned. The chicken does not need to be fully cooked.
    process shots showing how to make mississippi chicken casserole.
  • In a large bowl, whisk together 1 cup of chicken broth, 1 cup of sour cream, 1 cup of cream cheese, ½ cup of melted butter, and ¼ cup of pepperoncini juice until smooth.
    process shots showing how to make mississippi chicken casserole.
  • Add the cooked noodles, chicken, and ½ cup of sliced pepperoncini peppers to the sauce. Stir until everything is well coated.
    process shots showing how to make mississippi chicken casserole.
  • Fold in 1½ cups of mozzarella and ½ cup of cheddar.
    process shots showing how to make mississippi chicken casserole.
  • Transfer the mixture to the prepared baking dish. Sprinkle the remaining ½ cup of mozzarella and ½ cup of cheddar over the top. Bake uncovered for 40 to 45 minutes, until bubbly and lightly golden.
    process shots showing how to make mississippi chicken casserole.
  • Let the casserole rest for 5 minutes. Garnish with chopped parsley if using, then serve hot.

Video

Notes

  1. Make sure the cream cheese is fully softened so it blends smoothly into the sauce.
  2. Cook the egg noodles just until al dente. They’ll finish cooking in the oven and soak up the sauce without getting mushy.
  3. The chicken only needs to be lightly browned. It finishes cooking as the casserole bakes.
  4. Pepperoncini add tang, not heat. For extra kick, add more peppers or a bit more juice.
  5. Let the casserole rest for about 5 minutes before serving so it sets up and scoops cleanly.

Nutrition

Serving: 1serving | Calories: 964kcal | Carbohydrates: 49g | Protein: 57g | Fat: 59g | Saturated Fat: 32g | Polyunsaturated Fat: 4g | Monounsaturated Fat: 17g | Trans Fat: 1g | Cholesterol: 295mg | Sodium: 1179mg | Potassium: 885mg | Fiber: 2g | Sugar: 5g | Vitamin A: 1778IU | Vitamin C: 11mg | Calcium: 433mg | Iron: 2mg
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